General Information

  • ID:  hor004887
  • Uniprot ID:  P69058
  • Protein name:  Oxytocin
  • Gene name:  NA
  • Organism:  Hydrolagus colliei (Spotted ratfish) (Chimaera colliei)
  • Family:  Vasopressin/oxytocin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Hydrolagus (genus), Chimaeridae (family), Chimaeriformes (order), Holocephali (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005185 neurohypophyseal hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  CYIQNCPLG
  • Length:  9
  • Propeptide:  CYIQNCPLG
  • Signal peptide:  NA
  • Modification:  T9 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: Prostaglandin F metabolite(PGFM) release on administeration of 10 iu of oxytocin= 18.48±3.62 pg/ml ( PubMed ID: 10454085 )
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: 6.78 minutes; /406.8 seconds ( PubMed ID: 10454085 )

Structure

  • Disulfide bond:  1-6
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004887_AF2.pdbhor004887_ESM.pdb

Physical Information

Mass: 115308 Formula: C43H67N11O13S2
Absent amino acids: ADEFHKMRSTVW Common amino acids: C
pI: 5.81 Basic residues: 0
Polar residues: 5 Hydrophobic residues: 2
Hydrophobicity: 33.33 Boman Index: 102
Half-Life: 1.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 86.67
Instability Index: 2708.89 Extinction Coefficient cystines: 1615
Absorbance 280nm: 201.88

Literature

  • PubMed ID:  5366118##10454085
  • Title:  Oxytocin as a neurophyophysial hormone in the holocephalian elasmobranch fish, Hydrolagus collei.